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Multi-omic analysis of the ciliogenic transcription factor <i>RFX3</i> reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons

2025-03-01

Abstract excerpt

<h4>Summary</h4> Heterozygous loss-of-function (LoF) variants in RFX3, a transcription factor known to play key roles in ciliogenesis, result in autism spectrum disorder (ASD) and neurodevelopmental delay. RFX binding motifs are also enriched upstream of genes found to be commonly dysregulated in transcriptomic analyses of brain tissue from individuals with idiopathic ASD. Still, the precise functions of RFX3 i...

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Literature Corpus work
582fd027-ec24-54e8-8958-6623cd2622b4
DOI
10.1101/2025.02.27.640588
Open publication

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Multi-omic analysis of the ciliogenic transcription factor <i>RFX3</i> reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neuronsDOI 10.1101/2025.02.27.640588
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