Article
Intercellular coupling confers robustness against mutations in the SCN circadian clock network.
Cell - 4 May 2007
Liu Andrew C, Welsh David K, Ko Caroline H, Tran Hien G, Zhang Eric E, Priest Aaron A, Buhr Ethan D, Singer Oded, Meeker Kirsten, Verma Inder M, Doyle Francis J, Takahashi Joseph S, Kay Steve A
Abstract excerpt
Molecular mechanisms of the mammalian circadian clock have been studied primarily by genetic perturbation and behavioral analysis. Here, we used bioluminescence imaging to monitor Per2 gene expression in tissues and cells from clock mutant mice. We discovered that Per1 and Cry1 are required for sustained rhythms in peripheral tissues and cells, and in neurons dissociated from the suprachiasmatic nuclei (SCN)....
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