Article
Tuning the period of the mammalian circadian clock: additive and independent effects of CK1εTau and Fbxl3Afh mutations on mouse circadian behavior and molecular pacemaking.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 26 Jan 2011
Maywood Elizabeth S, Chesham Johanna E, Meng Qing-Jun, Nolan Patrick M, Loudon Andrew S I, Hastings Michael H
Abstract excerpt
Circadian pacemaking in the suprachiasmatic nucleus (SCN) revolves around a transcriptional/posttranslational feedback loop in which period (Per) and cryptochrome (Cry) genes are negatively regulated by their protein products. Genetically specified differences in this oscillator underlie sleep and metabolic disorders, and dictate diurnal/nocturnal preference. A critical goal, therefore, is to identify mechanisms...
Topics
- Animals
- Behavior, Animal
- Circadian Clocks
- Circadian Rhythm
- Crosses, Genetic
- Cryptochromes
- Epistasis, Genetic
- Feedback, Physiological
- Male
- Mice