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Article

From promoter motif to cardiac function: a single DPE motif affects transcription regulation and organ function in vivo.

Development (Cambridge, England) - 15 Jul 2024

Sloutskin Anna, Itzhak Dekel, Vogler Georg, Pozeilov Hadar, Ideses Diana, Alter Hadar, Adato Orit, Shachar Hadar, Doniger Tirza, Shohat-Ophir Galit, Frasch Manfred, Bodmer Rolf, Duttke Sascha H, Juven-Gershon Tamar

Abstract excerpt

Transcription initiates at the core promoter, which contains distinct core promoter elements. Here, we highlight the complexity of transcriptional regulation by outlining the effect of core promoter-dependent regulation on embryonic development and the proper function of an organism. We demonstrate in vivo the importance of the downstream core promoter element (DPE) in complex heart formation in Drosophila....

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Identifiers

PMID: 38958007
DOI: 10.1242/dev.202355
PMCID: PMC11317100

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