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Article

Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus.

Cell reports - 8 May 2014

Bedont Joseph L, LeGates Tara A, Slat Emily A, Byerly Mardi S, Wang Hong, Hu Jianfei, Rupp Alan C, Qian Jiang, Wong G William, Herzog Erik D, Hattar Samer, Blackshaw Seth

Abstract excerpt

Vertebrate circadian rhythms are organized by the hypothalamic suprachiasmatic nucleus (SCN). Despite its physiological importance, SCN development is poorly understood. Here, we show that Lim homeodomain transcription factor 1 (Lhx1) is essential for terminal differentiation and function of the SCN. Deletion of Lhx1 in the developing SCN results in loss of SCN-enriched neuropeptides involved in synchronization...

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Source

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Identifiers

PMID: 24767996
DOI: 10.1016/j.celrep.2014.03.060
PMCID: PMC4254772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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