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Article

Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.

Circulation research - 4 Dec 2020

van Eif Vincent W W, Protze Stephanie I, Bosada Fernanda M, Yuan Xuefei, Sinha Tanvi, van Duijvenboden Karel, Ernault Auriane C, Mohan Rajiv A, Wakker Vincent, de Gier-de Vries Corrie, Hooijkaas Ingeborg B, Wilson Michael D, Verkerk Arie O, Bakkers Jeroen, Boukens Bastiaan J, Black Brian L, Scott Ian C, Christoffels Vincent M

Abstract excerpt

RATIONALE: The development and function of the pacemaker cardiomyocytes of the sinoatrial node (SAN), the leading pacemaker of the heart, are tightly controlled by a conserved network of transcription factors, including TBX3 (T-box transcription factor 3), ISL1 (ISL LIM homeobox 1), and SHOX2 (short stature homeobox 2). Yet, the regulatory DNA elements (REs) controlling target gene expression in the SAN pacemaker...

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Identifiers

PMID: 33040635
DOI: 10.1161/CIRCRESAHA.120.317054
PMCID: PMC8153223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genome-Wide Analysis Identifies an Essential Human TBX3 Pacemaker Enhancer.PMID 33040635Read ↗

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