Article

Potent and selective repression of <i>SCN9A</i> by engineered zinc finger repressors for the treatment of neuropathic pain

2024-09-11

Abstract excerpt

<h4>ABSTRACT</h4> Peripheral neuropathies are estimated to affect several million patients in the US with no long-lasting therapy currently available. In humans, the Nav1.7 sodium channel, encoded by the SCN9A gene, is involved in a spectrum of inherited neuropathies, and has emerged as a promising target for analgesic drug development. The development of a selective Nav1.7 inhibitor has been challenging, in par...

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Literature Corpus work: 735d280e-8d45-54ba-8c5c-fa625f6e2f8e
DOI: 10.1101/2024.09.06.609976

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