Article
Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 24 Apr 2013
Anand Sneha N, Maywood Elizabeth S, Chesham Johanna E, Joynson Greg, Banks Gareth T, Hastings Michael H, Nolan Patrick M
Abstract excerpt
The circadian clock of the suprachiasmatic nucleus (SCN) drives daily rhythms of behavior. Cryptochromes (CRYs) are powerful transcriptional repressors within the molecular negative feedback loops at the heart of the SCN clockwork, where they periodically suppress their own expression and that of clock-controlled genes. To determine the differential contributions of CRY1 and CRY2 within circadian timing in vivo,...
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