Article

A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice

2022-05-25

Abstract excerpt

A protein altering variant in the gene encoding zinc finger homeobox-3 ( ZFHX3 ) has recently been associated with lower BMI in a human genome-wide association study. We investigated metabolic parameters in mice harbouring a missense mutation in Zfhx3 ( Zfhx3 Sci/+ ) and looked for altered in situ expression of transcripts that are associated with energy balance in the hypothalamus to understand how ZFHX3 may...

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Literature Corpus work: 9e1898a7-00c3-58d4-b931-d8e2b0cda51a
DOI: 10.1101/2022.05.25.493441

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A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in miceDOI 10.1101/2022.05.25.493441Read

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