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Article

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.

PloS one - 1 Jan 2015

Tijchon Esther, van Ingen Schenau Dorette, van Opzeeland Fred, Tirone Felice, Hoogerbrugge Peter M, Van Leeuwen Frank N, Scheijen Blanca

Abstract excerpt

Btg1 and Btg2 encode highly homologous proteins that are broadly expressed in different cell lineages, and have been implicated in different types of cancer. Btg1 and Btg2 have been shown to modulate the function of different transcriptional regulators, including Hox and Smad transcription factors. In this study, we examined the in vivo role of the mouse Btg1 and Btg2 genes in specifying the regional identity of...

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PMID: 26218146
DOI: 10.1371/journal.pone.0131481
PMCID: PMC4517811

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