Article
Cdx and T Brachyury Co-activate Growth Signaling in the Embryonic Axial Progenitor Niche.
Cell reports - 20 Dec 2016
Amin Shilu, Neijts Roel, Simmini Salvatore, van Rooijen Carina, Tan Sander C, Kester Lennart, van Oudenaarden Alexander, Creyghton Menno P, Deschamps Jacqueline
Abstract excerpt
In vertebrate embryos, anterior tissues are generated early, followed by the other axial structures that emerge sequentially from a posterior growth zone. The genetic network driving posterior axial elongation in mice, and its disturbance in mutants with posterior truncation, is not yet fully understood. Here, we show that the combined expression of Cdx2 and T Brachyury is essential to establish the core...
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