Article
Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.
Genes & development - 1 Jul 1995
Horan G S, Ramírez-Solis R, Featherstone M S, Wolgemuth D J, Bradley A, Behringer R R
Abstract excerpt
The Hox gene products are transcription factors involved in specifying regional identity along the anteroposterior body axis. In the mouse, several single mutants for Hox genes show variably penetrant, partial homeotic transformations of vertebrae at their anterior limits of expression, suggestin...
Topics
- Animals
- Cervical Vertebrae
- Crosses, Genetic
- Female
- Gene Expression
- Genes, Homeobox
- Genotype
- Heterozygote
- Male
- Mice
- Mice, Mutant Strains
- Multigene Family
- Mutation
- Phenotype
- Recombination, Genetic