Article
Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.
Developmental biology - 15 Aug 2009
Skuntz Susan, Mankoo Baljinder, Nguyen Minh-Thanh T, Hustert Elisabeth, Nakayama Atsuo, Tournier-Lasserve Elisabeth, Wright Christopher V E, Pachnis Vassilis, Bharti Kapil, Arnheiter Heinz
Abstract excerpt
Meox1 and Meox2 are two related homeodomain transcription factor genes that together are essential for the development of all somite compartments. Here we show that mice homozygous for Meox1 mutations alone have abnormalities that are restricted to the sclerotome and its derivatives. A prominent and consistent phenotype of these mutations is a remodeling of the cranio-cervical joints whose major feature is the...
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