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Article

B-cell translocation gene 2 (Btg2) regulates vertebral patterning by modulating bone morphogenetic protein/smad signaling.

Molecular and cellular biology - 1 Dec 2004

Park Sean, Lee Young Jae, Lee Ho-Jae, Seki Tsugio, Hong Kwon-Ho, Park Joonil, Beppu Hideyuki, Lim In Kyung, Yoon Ji-Won, Li En, Kim Seong-Jin, Oh S Paul

Abstract excerpt

Btg2 is a primary p53 transcriptional target gene which may function as a coactivator-corepressor and/or an adaptor molecule that modulates the activities of its interacting proteins. We have generated Btg2-null mice to elucidate the in vivo function of Btg2. Btg2-null mice are viable and fertile but exhibit posterior homeotic transformations of the axial vertebrae in a dose-dependent manner. Consistent with its...

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Identifiers

PMID: 15542835
DOI: 10.1128/MCB.24.23.10256-10262.2004
PMCID: PMC529031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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