Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.

PloS one - 1 Jan 2016

Melhuish Tiffany A, Taniguchi Kenichiro, Wotton David

Abstract excerpt

Tgif1 and Tgif2 are transcriptional repressors that inhibit the transcriptional response to transforming growth factor β signaling, and can repress gene expression by direct binding to DNA. Loss of function mutations in TGIF1 are associated with holoprosencephaly (HPE) in humans. In mice, embryos lacking both Tgif1 and Tgif2 fail to complete gastrulation, and conditional double null embryos that survive past...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Patterning
Share to Cervical Vertebrae
Share to Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Repressor Proteins

Share to Skeleton

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 27187787
DOI: 10.1371/journal.pone.0155837
PMCID: PMC4871493

Genes

TGIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tgif1 and Tgif2 Regulate Axial Patterning in Mouse.PMID 27187787Read ↗

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.Semantic proximity Read ↗

Loss of Tgif function causes holoprosencephaly by disrupting the SHH signaling pathway.Semantic proximity Read ↗

Targeted Deletion of Btg1 and Btg2 Results in Homeotic Transformation of the Axial Skeleton.Semantic proximity Read ↗

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.Semantic proximity Read ↗

The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF.Semantic proximity Read ↗

TGIF Inhibits Retinoid SignalingSemantic proximity Read ↗

Intragenic deletion of Tgif causes defectsin brain development.Semantic proximity Read ↗

Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling.Semantic proximity Read ↗

Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development.Semantic proximity Read ↗

Expression pattern of TG-interacting factor 2 during mouse development.Semantic proximity Read ↗

Tcf3: a transcriptional regulator of axis induction in the early embryo.Semantic proximity Read ↗

Functions of TGIF homeodomain proteins and their roles in normal brain development and holoprosencephaly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.