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Article

Mutation of a ubiquitously expressed mouse transmembrane protein (Tapt1) causes specific skeletal homeotic transformations.

Genetics - 1 Feb 2007

Howell Gareth R, Shindo Mami, Murray Stephen, Gridley Thomas, Wilson Lawriston A, Schimenti John C

Abstract excerpt

L5Jcs1 is a perinatal lethal mutation uncovered in a screen for ENU-induced mutations on mouse chromosome 5. L5Jcs1 homozygotes exhibit posterior-to-anterior transformations of the vertebral column midsection, similar to mice deficient for Hoxc8 and Hoxc9. Positional cloning efforts identified a mutation in a novel, evolutionarily conserved, and ubiquitously expressed gene dubbed Tapt1 (Transmembrane anterior...

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Source

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Identifiers

PMID: 17151244
DOI: 10.1534/genetics.106.065177
PMCID: PMC1800629

Genes

TAPT1
HOXC8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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