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Article

Developmental Patterning as a Quantitative Trait: Genetic Modulation of the Hoxb6 Mutant Skeletal Phenotype.

PloS one - 1 Jan 2016

Kappen Claudia

Abstract excerpt

The process of patterning along the anterior-posterior axis in vertebrates is highly conserved. The function of Hox genes in the axis patterning process is particularly well documented for bone development in the vertebral column and the limbs. We here show that Hoxb6, in skeletal elements at the cervico-thoracic junction, controls multiple independent aspects of skeletal pattern, implicating discrete...

Topics

Animals
Body Patterning
Bone Development
Cervical Vertebrae
Gene Expression Regulation, Developmental
Homeodomain Proteins
Mice
Mice, Inbred C57BL
Mice, Transgenic
Phenotype
Quantitative Trait Loci

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait, Heritable

Ribs

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Identifiers

PMID: 26800342
DOI: 10.1371/journal.pone.0146019
PMCID: PMC4723086

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