Article
Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development.
Molecular and cellular biology - 1 Aug 2002
Hildebrand Jeffrey D, Soriano Philippe
Abstract excerpt
The C-terminal binding protein (CtBP) family of proteins has been linked to multiple biological processes through their association with numerous transcription factors. We generated mice harboring mutations in both Ctbp1 and Ctbp2 to address the in vivo function of CtBPs during vertebrate development. Ctbp1 mutant mice are small but viable and fertile, whereas Ctbp2-null mice show defects in axial patterning and...
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