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Article

Axial skeletal patterning in mice lacking all paralogous group 8 Hox genes.

Development (Cambridge, England) - 1 May 2001

van den Akker E, Fromental-Ramain C, de Graaff W, Le Mouellic H, Brûlet P, Chambon P, Deschamps J

Abstract excerpt

We present a detailed study of the genetic basis of mesodermal axial patterning by paralogous group 8 Hox genes in the mouse. The phenotype of Hoxd8 loss-of-function mutants is presented, and compared with that of Hoxb8- and Hoxc8-null mice. Our analysis of single mutants reveals common features for the Hoxc8 and Hoxd8 genes in patterning lower thoracic and lumbar vertebrae. In the Hoxb8 mutant, more anterior...

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Identifiers

PMID: 11311170
DOI: 10.1242/dev.128.10.1911

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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