Synaptotagmins interact with APP and promote Aβ generation

Abstract excerpt

BACKGROUND: Accumulation of the β-amyloid peptide (Aβ) is a major pathological hallmark of Alzheimer's disease (AD). Recent studies have shown that synaptic Aβ toxicity may directly impair synaptic function. However, proteins regulating Aβ generation at the synapse have not been characterized. Here, we sought to identify synaptic proteins that interact with the extracellular domain of APP and regulate Aβ...

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