Article

ADAM10- and Presenilin 1/γ-Secretase-Dependent Cleavage of PTPRT Mitigates Neurodegeneration of Alzheimer’s Disease

2021-07-13

Abstract excerpt

<h4>Background: </h4> PTPRT (receptor-type tyrosine-protein phosphatase T), as a brain-specific type 1 transmembrane protein, plays an important function in neurodevelopment and synapse formation. However, whether PTPRT-dependent signaling is involved in Alzheimer’s disease (AD) remains elusive.MethodsHere, we first applied biochemistry methods and bioinformatic analysis to test and quantify the processing and exp...

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Literature Corpus work: 30358c2f-5139-5bec-adb0-700c12e88139
DOI: 10.21203/rs.3.rs-691466/v1

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