Article
Differential effects of familial Alzheimer's disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity.
Acta neuropathologica communications - 1 Jun 2023
Schilling Sandra, Pradhan Ajay, Heesch Amelie, Helbig Andrea, Blennow Kaj, Koch Christian, Bertgen Lea, Koo Edward H, Brinkmalm Gunnar, Zetterberg Henrik, Kins Stefan, Eggert Simone
Abstract excerpt
The amyloid precursor protein (APP) is a key player in Alzheimer`s disease (AD) and the precursor of the Aβ peptide, which is generated by consecutive cleavages of β- and γ-secretases. Familial Alzheimer's disease (FAD) describes a hereditary subgroup of AD that represents a low percentage of AD cases with an early onset of the disease. Different APP FAD mutations are thought to have qualitatively different...
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