Article

The phosphoS655 Alzheimer’s Amyloid Precursor Protein (APP) interactome in neuronal differentiation

2026-03-30

Abstract excerpt

The Alzheimer’s Amyloid Precursor Protein (APP) has determinant roles in neuronal development and function, both in its full-length conformation and as some of its proteolytic peptides, particularly secreted (s)APPa. Given that APP phosphorylation tightly regulates its trafficking, proteolysis, and protein-protein binding, it consequently affects several APP functions. The S655 residue, located in the basolateral...

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Literature Corpus work: 28ecc202-1440-55c3-8c6d-9dd8ef83416f
DOI: 10.64898/2026.03.26.714600

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