Article

APP-CTFβ/C99 oligomers drive synaptic vesicle tethering through C-terminal interactions

2026-06-30

Abstract excerpt

Proteolytic processing of the amyloid precursor protein (APP) generates a 99-amino acid precursor, β-carboxyl-terminal fragments (APP-CTFβ or C99). Upon γ-secretase inhibition, APP-CTFβ accumulates and induces synaptic defects, resulting in neuronal hyperactivity. However, mechanistic insights in the critical role of APP-CTFβ has not been completely elucidated. Here, we show that in primary neurons expressing huma...

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Literature Corpus work: a06bc677-bb3c-5cb9-baa2-b23d91defcf5
DOI: 10.64898/2026.06.25.734451

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