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Article

The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Dec 2015

Klevanski Maja, Herrmann Ulrike, Weyer Sascha W, Fol Romain, Cartier Nathalie, Wolfer David P, Caldwell John H, Korte Martin, Müller Ulrike C

Abstract excerpt

The amyloid precursor protein family (APP/APLPs) has essential roles for neuromuscular synapse development and for the formation and plasticity of synapses within the CNS. Despite this, it has remained unclear whether APP mediates its functions primarily as a cell surface adhesion and signaling molecule or via its numerous proteolytic cleavage products. To address these questions, we followed a genetic approach...

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Source

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Identifiers

PMID: 26658856
DOI: 10.1523/JNEUROSCI.2009-15.2015
PMCID: PMC6605503

Genes

APP
APLP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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