Article

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

2018-02-01

Abstract excerpt

<h4>SUMMARY</h4> Presenilin (PS), the catalytic subunit of γ-secretase and its main substrate the amyloid precursor protein (APP) are mutated in a large majority of patients with familial Alzheimer disease. PS and APP interact with proteins of the neurotransmitter release machinery but the functional consequences of these interactions are unknown. Here we report that genetic deletion of presynaptic PS markedly de...

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Literature Corpus work: 6d790895-bf3b-5490-a12a-a453ebd026b5
DOI: 10.1101/258335

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