Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.

The Journal of biological chemistry - 1 Nov 2013

Zhu Li, Zhong Minghao, Zhao Jiaying, Rhee Hannah, Caesar Ina, Knight Elysse M, Volpicelli-Daley Laura, Bustos Victor, Netzer William, Liu Lijuan, Lucast Louise, Ehrlich Michelle E, Robakis Nikolaos K, Gandy Samuel E, Cai Dongming

Abstract excerpt

Recent studies link synaptojanin 1 (synj1), the main phosphoinositol (4,5)-biphosphate phosphatase (PI(4,5)P2-degrading enzyme) in the brain and synapses, to Alzheimer disease. Here we report a novel mechanism by which synj1 reversely regulates cellular clearance of amyloid-β (Aβ). Genetic down-regulation of synj1 reduces both extracellular and intracellular Aβ levels in N2a cells stably expressing the Swedish...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Hippocampus

Share to Lysosomes

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Phosphoric Monoester Hydrolases

Share to Presenilin-1

Source

Open in PubMed Open full text

Identifiers

PMID: 24052255
DOI: 10.1074/jbc.M113.504365
PMCID: PMC3814799

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.PMID 24052255Read ↗

Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in miceSemantic proximity Read ↗

Synaptojanin 1 mutation in Parkinson's disease brings further insight into the neuropathological mechanisms.Semantic proximity Read ↗

Synaptojanin1 regulates lysosomal functions in ventral midbrain neuronsSemantic proximity Read ↗

Excess Synaptojanin 1 Contributes to Place Cell Dysfunction and Memory Deficits in the Aging Hippocampus in Three Types of Alzheimer's Disease.Semantic proximity Read ↗

The synucleins: a family of proteins involved in synaptic function, plasticity, neurodegeneration and diseaseSemantic proximity Read ↗

Alteration of endosomal trafficking is associated with early-onset parkinsonism caused by SYNJ1 mutations.Semantic proximity Read ↗

Haploinsufficiency of Parkinsonism Gene <i>SYNJ1</i> Contributes to Dopamine neuron Vulnerability in Aged MiceSemantic proximity Read ↗

Synapsin-caveolin-1 mitigates cognitive deficits and neurodegeneration in Alzheimer’s disease miceSemantic proximity Read ↗

Parkinson’s disease gene, Synaptojanin1, dysregulates the basal maintenance of the dopamine transporterSemantic proximity Read ↗

Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesisSemantic proximity Read ↗

Loss of SYNJ1 dual phosphatase activity leads to early onset refractory seizures and progressive neurological decline.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.