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Article

β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals.

Journal of neuropathology and experimental neurology - 1 Sept 2018

Wu Hsin-Yi, Kuo Po-Cheng, Wang Yi-Ting, Lin Hao-Tai, Roe Allyson D, Wang Bo Y, Han Chia-Li, Hyman Bradley T, Chen Yu-Ju, Tai Hwan-Ching

Abstract excerpt

A synergy between β-amyloid (Aβ) and tau appears to occur in Alzheimer disease (AD), but the mechanisms of interaction, and potential locations, are little understood. This study investigates the possibility of such interactions within the cortical synaptic compartments of APP/PS1 mice. We used label-free quantitative mass spectrometry to study the phosphoproteome of synaptosomes, covering 2400 phosphopeptides...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 30016458
DOI: 10.1093/jnen/nly059

Genes

APP
CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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