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Article

Synaptogenic effect of APP-Swedish mutation in familial Alzheimer's disease.

Science translational medicine - 19 Oct 2022

Zhou Bo, Lu Jacqueline G, Siddu Alberto, Wernig Marius, Südhof Thomas C

Abstract excerpt

Mutations in β-amyloid (Aβ) precursor protein (APP) cause familial Alzheimer's disease (AD) probably by enhancing Aβ peptides production from APP. An antibody targeting Aβ (aducanumab) was approved as an AD treatment; however, some Aβ antibodies have been reported to accelerate, instead of ameliorating, cognitive decline in individuals with AD. Using conditional APP mutations in human neurons for perfect isogenic...

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Identifiers

PMID: 36260691
DOI: 10.1126/scitranslmed.abn9380
PMCID: PMC9894682

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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