Article
Paired exome analysis of Barrett's esophagus and adenocarcinoma.
Nature genetics - 1 Sept 2015
Stachler Matthew D, Taylor-Weiner Amaro, Peng Shouyong, McKenna Aaron, Agoston Agoston T, Odze Robert D, Davison Jon M, Nason Katie S, Loda Massimo, Leshchiner Ignaty, Stewart Chip, Stojanov Petar, Seepo Sara, Lawrence Michael S, Ferrer-Torres Daysha, Lin Jules, Chang Andrew C, Gabriel Stacey B, Lander Eric S, Beer David G, Getz Gad, Carter Scott L, Bass Adam J
Abstract excerpt
Barrett's esophagus is thought to progress to esophageal adenocarcinoma (EAC) through a stepwise progression with loss of CDKN2A followed by TP53 inactivation and aneuploidy. Here we present whole-exome sequencing from 25 pairs of EAC and Barrett's esophagus and from 5 patients whose Barrett's esophagus and tumor were extensively sampled. Our analysis showed that oncogene amplification typically occurred as a...
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