Article
The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.
Gastroenterology - 1 Sept 2017
Contino Gianmarco, Vaughan Thomas L, Whiteman David, Fitzgerald Rebecca C
Abstract excerpt
We have recently gained unprecedented insight into genetic factors that determine risk for Barrett's esophagus (BE) and progression to esophageal adenocarcinoma (EA). Next-generation sequencing technologies have allowed us to identify somatic mutations that initiate BE and track genetic changes during development of tumors and invasive cancer. These technologies led to identification of mechanisms of...
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