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Article

Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma.

Nature genetics - 1 Sept 2015

Ross-Innes Caryn S, Becq Jennifer, Warren Andrew, Cheetham R Keira, Northen Helen, O'Donovan Maria, Malhotra Shalini, di Pietro Massimiliano, Ivakhno Sergii, He Miao, Weaver Jamie M J, Lynch Andy G, Kingsbury Zoya, Ross Mark, Humphray Sean, Bentley David, Fitzgerald Rebecca C

Abstract excerpt

The molecular genetic relationship between esophageal adenocarcinoma (EAC) and its precursor lesion, Barrett's esophagus, is poorly understood. Using whole-genome sequencing on 23 paired Barrett's esophagus and EAC samples, together with one in-depth Barrett's esophagus case study sampled over time and space, we have provided the following new insights: (i) Barrett's esophagus is polyclonal and highly mutated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26192915
DOI: 10.1038/ng.3357
PMCID: PMC4556068

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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