Article
Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2021
Sihag Smita, Nussenzweig Samuel C, Walch Henry S, Hsu Meier, Tan Kay See, Sanchez-Vega Francisco, Chatila Walid K, De La Torre Sergio A, Patel Assem, Janjigian Yelena Y, Maron Steven, Ku Geoffrey Y, Tang Laura H, Hechtman Jaclyn, Shah Pari M, Wu Abraham J, Jones David R, Molena Daniela, Solit David B, Schultz Nikolaus, Berger Michael F
Abstract excerpt
PURPOSE: To delineate recurrent oncogenic driver alterations and dysregulated pathways in esophageal adenocarcinoma and to assess their prognostic value. EXPERIMENTAL DESIGN: We analyzed a large cohort of patients with lower esophageal and junctional adenocarcinoma, prospectively sequenced by MSK-IMPACT with high-quality clinical annotation. Patients were subdivided according to treatment intent, curative versus...
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