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Article

Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2014

Li Xiaohong, Galipeau Patricia C, Paulson Thomas G, Sanchez Carissa A, Arnaudo Jessica, Liu Karen, Sather Cassandra L, Kostadinov Rumen L, Odze Robert D, Kuhner Mary K, Maley Carlo C, Self Steven G, Vaughan Thomas L, Blount Patricia L, Reid Brian J

Abstract excerpt

All cancers are believed to arise by dynamic, stochastic somatic genomic evolution with genome instability, generation of diversity, and selection of genomic alterations that underlie multistage progression to cancer. Advanced esophageal adenocarcinomas have high levels of somatic copy number alterations. Barrett's esophagus is a risk factor for developing esophageal adenocarcinoma, and somatic chromosomal...

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Identifiers

PMID: 24253313
DOI: 10.1158/1940-6207.CAPR-13-0289
PMCID: PMC3904552

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