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Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progression

28 Apr 2022

Abstract excerpt

While the genomes of normal tissues undergo dynamic changes over time, little is understood about the temporal-spatial dynamics of genomes in premalignant tissues that progress to cancer compared to those that remain cancer-free. Here we use whole genome sequencing to contrast genomic alterations in 427 longitudinal samples from 40 patients with stable Barrett's esophagus compared to 40 Barrett's patients who...

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PMID: 35484108
DOI: 10.1038/s41467-022-29767-7

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