Article
Exome and whole-genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity.
Nature genetics - 1 May 2013
Dulak Austin M, Stojanov Petar, Peng Shouyong, Lawrence Michael S, Fox Cameron, Stewart Chip, Bandla Santhoshi, Imamura Yu, Schumacher Steven E, Shefler Erica, McKenna Aaron, Carter Scott L, Cibulskis Kristian, Sivachenko Andrey, Saksena Gordon, Voet Douglas, Ramos Alex H, Auclair Daniel, Thompson Kristin, Sougnez Carrie, Onofrio Robert C, Guiducci Candace, Beroukhim Rameen, Zhou Zhongren, Lin Lin, Lin Jules, Reddy Rishindra, Chang Andrew, Landrenau Rodney, Pennathur Arjun, Ogino Shuji, Luketich James D, Golub Todd R, Gabriel Stacey B, Lander Eric S, Beer David G, Godfrey Tony E, Getz Gad, Bass Adam J
Abstract excerpt
The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years. With a 5-year survival rate of ~15%, the identification of new therapeutic targets for EAC is greatly important. We analyze the mutation spectra from whole-exome sequencing of 149 EAC tumor-normal pairs, 15 of which have also been subjected to whole-genome sequencing. We identify a mutational signature defined by a high...
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