Article
Studying Cancer Evolution in Barrett's Esophagus and Esophageal Adenocarcinoma.
Advances in experimental medicine and biology - 1 Jan 2000
Paulson Thomas G
Abstract excerpt
Technological advances in genome sequencing and copy number analysis have allowed researchers to catalog the wide variety of genomic alterations that occur across diverse cancer types. For most cancer types, the lack of high-frequency alterations and the heterogeneity observed both within and between tumors suggest neoplastic progression proceeds through a branched evolutionary pathway as proposed by Nowell in...
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