Article
Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma.
Cancer discovery - 1 Oct 2012
Agrawal Nishant, Jiao Yuchen, Bettegowda Chetan, Hutfless Susan M, Wang Yuxuan, David Stefan, Cheng Yulan, Twaddell William S, Latt Nyan L, Shin Eun J, Wang Li-Dong, Wang Liang, Yang Wancai, Velculescu Victor E, Vogelstein Bert, Papadopoulos Nickolas, Kinzler Kenneth W, Meltzer Stephen J
Abstract excerpt
Esophageal cancer ranks sixth in cancer death. To explore its genetic origins, we conducted exomic sequencing on 11 esophageal adenocarcinomas (EAC) and 12 esophageal squamous cell carcinomas (ESCC) from the United States. Interestingly, inactivating mutations of NOTCH1 were identified in 21% of ESCCs but not in EACs. There was a substantial disparity in the spectrum of mutations, with more indels in ESCCs,...
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