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Article

Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing.

Nature communications - 12 Sept 2017

Chen Xi-Xi, Zhong Qian, Liu Yang, Yan Shu-Mei, Chen Zhang-Hua, Jin Shan-Zhao, Xia Tian-Liang, Li Ruo-Yan, Zhou Ai-Jun, Su Zhe, Huang Yu-Hua, Huang Qi-Tao, Huang Li-Yun, Zhang Xing, Zhao Yan-Na, Yun Jin-Ping, Wu Qiu-Liang, Lin Dong-Xin, Bai Fan, Zeng Mu-Sheng

Abstract excerpt

Esophageal squamous dysplasia is believed to be the precursor lesion of esophageal squamous cell carcinoma (ESCC); however, the genetic evolution from dysplasia to ESCC remains poorly understood. Here, we applied multi-region whole-exome sequencing to samples from two cohorts, 45 ESCC patients with matched dysplasia and carcinoma samples, and 13 tumor-free patients with only dysplasia samples. Our analysis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28900112
DOI: 10.1038/s41467-017-00650-0
PMCID: PMC5595870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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