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Article

Comprehensive Genomic Profiling of Advanced Esophageal Squamous Cell Carcinomas and Esophageal Adenocarcinomas Reveals Similarities and Differences.

The oncologist - 1 Oct 2015

Wang Kai, Johnson Adrienne, Ali Siraj M, Klempner Samuel J, Bekaii-Saab Tanios, Vacirca Jeffrey L, Khaira Depinder, Yelensky Roman, Chmielecki Juliann, Elvin Julia A, Lipson Doron, Miller Vincent A, Stephens Philip J, Ross Jeffrey S

Abstract excerpt

BACKGROUND: Esophageal squamous cell carcinomas (ESCCs) and esophageal adenocarcinomas (EACs) account for >95% of esophageal malignancies and represent a major global health burden. ESCC is the dominant histology globally but represents a minority of U.S. cases, with EAC accounting for the majority of U.S. CASES: The patient outcomes for advanced ESCC and EAC are poor, and new therapeutic options are needed....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26336083
DOI: 10.1634/theoncologist.2015-0156
PMCID: PMC4591943

Genes

ERBB2
KRAS
NOTCH1
PTEN
MTOR
SMAD4
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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