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Article

Molecular phenotyping reveals the identity of Barrett's esophagus and its malignant transition.

Science (New York, N.Y.) - 13 Aug 2021

Nowicki-Osuch Karol, Zhuang Lizhe, Jammula Sriganesh, Bleaney Christopher W, Mahbubani Krishnaa T, Devonshire Ginny, Katz-Summercorn Annalise, Eling Nils, Wilbrey-Clark Anna, Madissoon Elo, Gamble John, Di Pietro Massimiliano, O'Donovan Maria, Meyer Kerstin B, Saeb-Parsy Kourosh, Sharrocks Andrew D, Teichmann Sarah A, Marioni John C, Fitzgerald Rebecca C

Abstract excerpt

The origin of human metaplastic states and their propensity for cancer is poorly understood. Barrett's esophagus is a common metaplastic condition that increases the risk for esophageal adenocarcinoma, and its cellular origin is enigmatic. To address this, we harvested tissues spanning the gastroesophageal junction from healthy and diseased donors, including isolation of esophageal submucosal glands. A...

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PMID: 34385390
DOI: 10.1126/science.abd1449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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