Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

doi:10.1038/ng.3013

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.

Nature genetics - 1 Aug 2014

Weaver Jamie M J, Ross-Innes Caryn S, Shannon Nicholas, Lynch Andy G, Forshew Tim, Barbera Mariagnese, Murtaza Muhammed, Ong Chin-Ann J, Lao-Sirieix Pierre, Dunning Mark J, Smith Laura, Smith Mike L, Anderson Charlotte L, Carvalho Benilton, O'Donovan Maria, Underwood Timothy J, May Andrew P, Grehan Nicola, Hardwick Richard, Davies Jim, Oloumi Arusha, Aparicio Sam, Caldas Carlos, Eldridge Matthew D, Edwards Paul A W, Rosenfeld Nitzan, Tavaré Simon, Fitzgerald Rebecca C

Abstract excerpt

Cancer genome sequencing studies have identified numerous driver genes, but the relative timing of mutations in carcinogenesis remains unclear. The gradual progression from premalignant Barrett's esophagus to esophageal adenocarcinoma (EAC) provides an ideal model to study the ordering of somatic mutations. We identified recurrently mutated genes and assessed clonal structure using whole-genome sequencing and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Barrett Esophagus

Share to Carcinogenesis

Share to Esophageal Neoplasms

Share to Genome-Wide Association Study

Share to Precancerous Conditions

Share to Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 24952744
DOI: 10.1038/ng.3013
PMCID: PMC4116294

Genes

HGD
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis.PMID 24952744Read ↗

Somatic whole genome dynamics of precancer in Barrett’s esophagus reveals features associated with disease progressionSemantic proximity Read ↗

The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.Semantic proximity Read ↗

Studying Cancer Evolution in Barrett's Esophagus and Esophageal Adenocarcinoma.Semantic proximity Read ↗

Somatic whole genome dynamics of precancer in Barrett’s EsophagusSemantic proximity Read ↗

Driver genes, mutational signatures and the timing of mutations in oesophageal adenocarcinomaSemantic proximity Read ↗

Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activitySemantic proximity Read ↗

Evolution and progression of Barrett's oesophagus to oesophageal cancer.Semantic proximity Read ↗

Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus.Semantic proximity Read ↗

Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma.Semantic proximity Read ↗

Assessment of Esophageal Adenocarcinoma Risk Using Somatic Chromosome Alterations in Longitudinal Samples in Barrett's Esophagus.Semantic proximity Read ↗

Genomic comparison of esophageal squamous cell carcinoma and its precursor lesions by multi-region whole-exome sequencing.Semantic proximity Read ↗

Genetic Insights in Barrett's Esophagus and Esophageal Adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.