Article
Molecular characterization of Barrett's esophagus at single-cell resolution.
Proceedings of the National Academy of Sciences of the United States of America - 23 Nov 2021
Busslinger Georg A, de Barbanson Buys, Oka Rurika, Weusten Bas L A, de Maat Michiel, van Hillegersberg Richard, Brosens Lodewijk A A, van Boxtel Ruben, van Oudenaarden Alexander, Clevers Hans
Abstract excerpt
Barrett's esophagus (BE) is categorized, based on morphological appearance, into different stages, which correlate with the risk of developing esophageal adenocarcinoma. More advanced stages are more likely to acquire chromosomal instabilities, but stage-specific markers remain elusive. Here, we performed single-cell DNA-sequencing experiments (scDNAseq) with fresh BE biopsies. Dysplastic BE cells frequently...
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