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Article

Evolution of Barrett's esophagus through space and time at single-crypt and whole-biopsy levels.

Nature communications - 23 Feb 2018

Martinez Pierre, Mallo Diego, Paulson Thomas G, Li Xiaohong, Sanchez Carissa A, Reid Brian J, Graham Trevor A, Kuhner Mary K, Maley Carlo C

Abstract excerpt

The low risk of progression of Barrett's esophagus (BE) to esophageal adenocarcinoma can lead to over-diagnosis and over-treatment of BE patients. This may be addressed through a better understanding of the dynamics surrounding BE malignant progression. Although genetic diversity has been characterized as a marker of malignant development, it is still unclear how BE arises and develops. Here we uncover the...

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Source

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Identifiers

PMID: 29476056
DOI: 10.1038/s41467-017-02621-x
PMCID: PMC5824808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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