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Article

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 2015

Hearn Jessica M, Romero-Canelón Isolda, Munro Alison F, Fu Ying, Pizarro Ana M, Garnett Mathew J, McDermott Ultan, Carragher Neil O, Sadler Peter J

Abstract excerpt

The organometallic "half-sandwich" compound [Os(η(6)-p-cymene)(4-(2-pyridylazo)-N,N-dimethylaniline)I]PF6 is 49× more potent than the clinical drug cisplatin in the 809 cancer cell lines that we screened and is a candidate drug for cancer therapy. We investigate the mechanism of action of compound 1 in A2780 epithelial ovarian cancer cells. Whole-transcriptome sequencing identified three missense mutations in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasms, Glandular and Epithelial

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Identifiers

PMID: 26162681
DOI: 10.1073/pnas.1500925112
PMCID: PMC4517206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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