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Article

Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study

20 Jan 2025

Abstract excerpt

Introduction: Ovarian cancer has been difficult to cure due to acquired or intrinsic resistance and therefore, newer or more effective drugs/approaches are needed for a successful treatment in the clinic. Erastin (ER), a ferroptosis inducer, kills tumor cells by generating and accumulating reactive oxygen species (ROS) within the cell, resulting in an iron-dependent oxidative damage-mediated ferroptotic cell...

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PMID: 39902375
DOI: 10.3389/fmolb.2024.1520876

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