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Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer †

19 Sept 2022

Abstract excerpt

Ovarian cancer is the most lethal gynecologic malignancy with a stubborn mortality rate of ~65%. The persistent failure of multiline chemotherapy, and significant tumor heterogeneity, has made it challenging to improve outcomes. A target of increasing interest is the mitochondrion because of its essential role in critical cellular functions, and the significance of metabolic adaptation in chemoresistance. This...

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PMID: 36117466
DOI: 10.1111/php.13723

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