Article

Platinum-Induced Mitochondrial OXPHOS Contributes to Cancer Stem Cell Enrichment in Ovarian Cancer

2022-02-03

Abstract excerpt

<h4>Background</h4> Platinum based agents – cisplatin and carboplatin in combination with taxanes are used for the treatment of ovarian cancer (OC) patients. However, the majority of OC patients develop recurrent, platinum resistant disease that is uniformly fatal. Acute platinum treatment enriches for chemoresistant aldehyde dehydrogenase (ALDH) + ovarian cancer stem cells (OCSCs), which contribute to tumor recu...

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Literature Corpus work: e48d44d5-da4f-5501-83e1-5374c5451374
DOI: 10.1101/2022.02.01.478738

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