Article

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid Leukemia

2019-01-15

Abstract excerpt

Inhibition of oxidative phosphorylation (OXPHOS) is a promising therapeutic strategy in Acute Myeloid Leukemia (AML), but patients respond heterogeneously. Through chemically interrogation of 200 sequenced specimens, we identified Mubritinib as a strong in vitro and in vivo anti-leukemic compound, acting through ubiquinone-dependent inhibition of Electron Transport Chain complex I (ETC1). ETC1 targeting showed s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a5c55584-c206-53cf-807d-ca5d64f66e8f
DOI: 10.1101/513887

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Landscape of Electron Transport Chain Complex I Dependency in Acute Myeloid LeukemiaDOI 10.1101/513887Read

Characterization of Mutations in the Mitochondrial Encoded Electron Transport Chain Complexes in Acute Myeloid Leukemia.Semantic proximity Read

OXPHOS mediators in acute myeloid leukemia patients: Prognostic biomarkers and therapeutic targets for personalized medicine.Semantic proximity Read

LncRNA BCYRN1 regulates mitochondrial MT-ND1/4/5 transcription via heavy strand promoter methylation to promote oxidative phosphorylation and proliferation in acute myeloid leukemiaSemantic proximity Read

Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemiaSemantic proximity Read

Mitochondrial DNA Mutations Determine Favourable Molecular Responses to Targeted Kinase Inhibitor Therapy and Impair Oxidative PhosphorylationSemantic proximity Read

The ferroptosis landscape in acute myeloid leukemia.Semantic proximity Read

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid LeukemiaSemantic proximity Read

Mitochondrial complex I inhibition by homoharringtonine: A novel strategy for suppression of chronic myeloid leukemia.Semantic proximity Read

Mitochondrial metabolism as a target for acute myeloid leukemia treatmentSemantic proximity Read

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia.Semantic proximity Read

Targeting mitochondrial respiration and the BCL2 family in MYC-associated B-cell lymphomaSemantic proximity Read

Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemiaSemantic proximity Read