Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.

doi:10.1016/j.redox.2019.101374

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.

Redox biology - 1 Jan 2020

Byrne Frances L, Olzomer Ellen M, Marriott Gabriella R, Quek Lake-Ee, Katen Alice, Su Jacky, Nelson Marin E, Hart-Smith Gene, Larance Mark, Sebesfi Veronica F, Cuff Jeff, Martyn Gabriella E, Childress Elizabeth, Alexopoulos Stephanie J, Poon Ivan K, Faux Maree C, Burgess Antony W, Reid Glen, McCarroll Joshua A, Santos Webster L, Quinlan Kate Gr, Turner Nigel, Fazakerley Daniel J, Kumar Naresh, Hoehn Kyle L

Abstract excerpt

A hallmark of cancer cells is their ability to reprogram nutrient metabolism. Thus, disruption to this phenotype is a potential avenue for anti-cancer therapy. Herein we used a phenotypic chemical library screening approach to identify molecules that disrupted nutrient metabolism (by increasing cellular oxygen consumption rate) and were toxic to cancer cells. From this screen we discovered a 1,4-Naphthoquinone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzoquinones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Doxorubicin

Share to Glycolysis

Share to Lactams, Macrocyclic

Share to Naphthoquinones

Share to Oxygen Consumption

Share to Small Molecule Libraries

Share to Vitamin K 3

Source

Open in PubMed Open full text

Identifiers

PMID: 31743887
DOI: 10.1016/j.redox.2019.101374
PMCID: PMC6861633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress.PMID 31743887Read ↗

Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms.Semantic proximity Read ↗

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-KetoglutarateSemantic proximity Read ↗

Metabolic profiling of hypoxic cells revealed a catabolic signature required for cell survival.Semantic proximity Read ↗

Metabolic Reprogramming: A Friend or Foe to Cancer Therapy?Semantic proximity Read ↗

Reactive oxygen species (ROS) are a key determinant of cancer's metabolic phenotype.Semantic proximity Read ↗

Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyondSemantic proximity Read ↗

Design, Synthesis, and Efficacy of Novel Trojan Horse Compounds Targeting Metabolic Vulnerabilities in Prostate CancerSemantic proximity Read ↗

Functional linkage between mitochondrial electron transport, glycolysis, and AMP-activated protein kinase signaling underlying cancer cell survivalSemantic proximity Read ↗

Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response.Semantic proximity Read ↗

Metabolic reprogramming of oncogene-addicted cancer cells to OXPHOS as a mechanism of drug resistanceSemantic proximity Read ↗

Mitochondrial metabolism as a target for acute myeloid leukemia treatmentSemantic proximity Read ↗

Mitochondrial VDAC1 Silencing Leads to Metabolic Rewiring and the Reprogramming of Tumour Cells into Advanced Differentiated StatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.